The Influence of Dietary Protein Source on Longevity and Age-Related Disease Processes of Fischer Rats

doi:10.1093/geronj/43.1.B5

Journal of Gerontology 1988 43(1):B5-B12; doi:10.1093/geronj/43.1.B5

This Article

	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Add to My Personal Archive
	Download to citation manager
	Request Permissions

Google Scholar

	Articles by Iwasaki, K.
	Articles by Yu, B. P.
	Search for Related Content

PubMed

	PubMed Citation

Social Bookmarking

	What's this?

The Influence of Dietary Protein Source on Longevity and Age-Related Disease Processes of Fischer Rats

Keisuke Iwasaki¹, Chester A. Gleiser², Edward J. Masoro¹, C. Alex McMahan², Eun-Joo Seo¹ and Byung Pal Yu¹

^¹ Department of Physiology the University of Texas Health Science Center At San Antonio
^² Department of Pathology the University of Texas Health Science Center At San Antonio

Abstract

The influence of replacing dietary casein with soy protein onlongevity and age-related pathologic lesions of male Fischer344 rats was investigated. Caloric intake and body weights weresimilar for rats on the two diets. Rats on the soy protein-containingdiet had a median length of life of 844 days compared to 730days for those on the caseincontaining diet (p < .002), andthe ages of the 10th percentile survivors were 937 and 857 days,respectively (p > .02). The progression of chronic nephropathywas markedly retarded by replacing casein with soy protein.Only 7% of the rats dying spontaneously on the soy protein-containingdiet exhibited end-stage chronic nephropathy compared to 41% of the rats on the casein-containing diet. Clearly, the soyprotein-containing diet enables ad libitum fed male Fischer344 rats to be used as a model for aging research without theoccurrence of renal failure as a major confounding problem

Received for publication December 12, 1986. Accepted for publication July 7, 1987.

Add to CiteULike CiteULike Add to Connotea Connotea Add to Del.icio.us Del.icio.us What's this?

This article has been cited by other articles:

J. L. Tarry-Adkins, J. A. Joles, J.-H. Chen, M. S. Martin-Gronert, D. M. van der Giezen, R. Goldschmeding, C. N. Hales, and S. E. Ozanne
Protein restriction in lactation confers nephroprotective effects in the male rat and is associated with increased antioxidant expression
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1259 - R1266.
[Abstract] [Full Text] [PDF]

K. P. Keenan, C.-M. Hoe, L. Mixson, C. L. Mccoy, J. B. Coleman, B. A. Mattson, G. A. Ballam, L. A. Gumprecht, and K. A. Soper
Diabesity: A Polygenic Model of Dietary-Induced Obesity from Ad Libitum Overfeeding of Sprague-Dawley Rats and Its Modulation by Moderate and Marked Dietary Restriction
Toxicol Pathol, October 1, 2005; 33(6): 650 - 674.
[Abstract] [Full Text] [PDF]

M. D. W. Piper, W. Mair, and L. Partridge
Counting the Calories: The Role of Specific Nutrients in Extension of Life Span by Food Restriction
J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2005; 60(5): 549 - 555.
[Abstract] [Full Text] [PDF]

D. L. Mattson, C. J. Meister, and M. L. Marcelle
Dietary Protein Source Determines the Degree of Hypertension and Renal Disease in the Dahl Salt-Sensitive Rat
Hypertension, April 1, 2005; 45(4): 736 - 741.
[Abstract] [Full Text] [PDF]

W. T. Cefalu, Z. Q. Wang, A. D. Bell-Farrow, J. Collins, T. Morgan, and J. D. Wagner
Caloric Restriction and Cardiovascular Aging in Cynomolgus Monkeys (Macaca fascicularis): Metabolic, Physiologic, and Atherosclerotic Measures From a 4-Year Intervention Trial
J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2004; 59(10): B1007 - B1014.
[Abstract] [Full Text] [PDF]

J. W. Kim, Y. Zou, S. Yoon, J. H. Lee, Y. K. Kim, B. P. Yu, and H. Y. Chung
Vascular Aging: Molecular Modulation of the Prostanoid Cascade by Calorie Restriction
J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2004; 59(9): B876 - B885.
[Abstract] [Full Text] [PDF]

D. E. Fair, M. R. Ogborn, H. A. Weiler, N. Bankovic-Calic, E. P. Nitschmann, S. C. Fitzpatrick-Wong, and H. M. Aukema
Dietary Soy Protein Attenuates Renal Disease Progression After 1 and 3 Weeks in Han:SPRD-cy Weanling Rats
J. Nutr., June 1, 2004; 134(6): 1504 - 1507.
[Abstract] [Full Text] [PDF]

G. C. Hard and Kanwar Nasir Khan
Invited Review: A Contemporary Overview of Chronic Progressive Nephropathy in the Laboratory Rat, and Its Significance for Human Risk Assessment
Toxicol Pathol, February 1, 2004; 32(2): 171 - 180.
[Abstract] [PDF]

D. J. Holmes
F344 Rat
Sci. Aging Knowl. Environ., September 10, 2003; 2003(36): as2 - 2.
[Abstract] [Full Text]

B. S. Kristal and U. Paolucci
Caloric Restriction in trans
Sci. Aging Knowl. Environ., July 9, 2003; 2003(27): pe19 - 19.
[Abstract] [Full Text]

S. R. Teixeira, K. A. Tappenden, and J. W. Erdman Jr.
Altering Dietary Protein Type and Quantity Reduces Urinary Albumin Excretion without Affecting Plasma Glucose Concentrations in BKS.cg-m +Leprdb/+Leprdb (db/db) Mice
J. Nutr., March 1, 2003; 133(3): 673 - 678.
[Abstract] [Full Text] [PDF]

G. N. Rao
Diet and Kidney Diseases in Rats
Toxicol Pathol, October 1, 2002; 30(6): 651 - 656.
[Abstract] [PDF]

H. Shi, K. E. Vigneau-Callahan, A. I. Shestopalov, P. E. Milbury, W. R. Matson, and B. S. Kristal
Characterization of Diet-Dependent Metabolic Serotypes: Proof of Principle in Female and Male Rats
J. Nutr., May 1, 2002; 132(5): 1031 - 1038.
[Abstract] [Full Text] [PDF]

H. Shi, K. E. Vigneau-Callahan, A. I. Shestopalov, P. E. Milbury, W. R. Matson, and B. S. Kristal
Characterization of Diet-Dependent Metabolic Serotypes: Primary Validation of Male and Female Serotypes in Independent Cohorts of Rats
J. Nutr., May 1, 2002; 132(5): 1039 - 1046.
[Abstract] [Full Text] [PDF]

G. N. Rao, R. W. Morris, and J. C. Seely
Beneficial Effects of NTP-2000 Diet on Growth, Survival, and Kidney and Heart Diseases of Fischer 344 Rats in Chronic Studies
Toxicol. Sci., October 1, 2001; 63(2): 245 - 255.
[Abstract] [Full Text] [PDF]

S. Molon-Noblot, K. P. Keenan, J. B. Coleman, C.-M. Hoe, and P. Laroque
The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pancreatic Islet Pathology in Sprague--Dawley Rats
Toxicol Pathol, April 1, 2001; 29(3): 353 - 362.
[Abstract] [PDF]

K. E. Vigneau-Callahan, A. I. Shestopalov, P. E. Milbury, W. R. Matson, and B. S. Kristal
Characterization of Diet-Dependent Metabolic Serotypes: Analytical and Biological Variability Issues in Rats
J. Nutr., March 1, 2001; 131(3): 924S - 932.
[Abstract] [Full Text]

M. Kemi, K. P. Keenan, C. Mccoy, C.-M. Hoe, K. A. Soper, G. C. Ballam, and M. J. Van Zwieten
The Relative Protective Effects of Moderate Dietary Restriction versus Dietary Modification on Spontaneous Cardiomyopathy in Male Sprague-Dawley Rats
Toxicol Pathol, March 1, 2000; 28(2): 285 - 296.
[Abstract] [PDF]

H. M. AUKEMA, I. HOUSINI, and J. M. RAWLING
Dietary Soy Protein Effects on Inherited Polycystic Kidney Disease Are Influenced by Gender and Protein Level
J. Am. Soc. Nephrol., February 1, 1999; 10(2): 300 - 308.
[Abstract] [Full Text]

K. P Keenan
Effects of Diet and Overfeeding On Body Weight and Survival in the Rodent Bioassay: the Impact On Pharmaceutical Safety Assessment
International Journal of Toxicology, January 1, 1998; 17(2_suppl): 101 - 117.
[Abstract] [PDF]

S. Klebanov, J. T. Herlihy, and G. L. Freeman
Effect of long-term food restriction on cardiac mechanics
Am J Physiol Heart Circ Physiol, November 1, 1997; 273(5): H2333 - H2342.
[Abstract] [Full Text] [PDF]

K. P Keenan, P. Laroque, G. C. Ballam, K. A. Soper, R. Dixit, B. A. Mattson, S. P Adams, and J. B. Coleman
The Effects of Diet, Ad Libitum Overfeeding, and Moderate Dietary Restriction on the Rodent Bioassay: The Uncontrolled Variable in Safety Assessment
Toxicol Pathol, November 1, 1996; 24(6): 757 - 768.
[Abstract] [PDF]

K. P. Keenan
Commentary: The Uncontrolled Variable in Risk Assessment: Ad Libitum Overfed Rodents-Fat, Facts and Fiction
Toxicol Pathol, May 1, 1996; 24(3): 376 - 383.
[PDF]

K. P. Keenan, K. A. Soper, P. R. Hertzog, L. A. Gumprecht, P. F. Smith, B. A. Mattson, G. C. Ballam, and R. L. Clark
Diet, Overfeeding, and Moderate Dietary Restriction in Control Sprague-Dawley Rats: II. Effects on Age-Related Proliferative and Degenerative Lesions
Toxicol Pathol, May 1, 1995; 23(3): 287 - 302.
[Abstract] [PDF]

L. A. Gumprecht, C. Y. R. Long, K. A. Soper, P. F. Smith, W. M. Haschek-Hock, and K. P. Keenan
The Early Effects of Dietary Restriction on the Pathogenesis of Chronic Renal Disease in Sprague-Dawley Rats at 12 Months
Toxicol Pathol, November 1, 1993; 21(6): 528 - 537.
[Abstract] [PDF]

G. N. Rao, J. Edmondson, and M. R. Elwell
Influence of Dietary Protein Concentration on Severity of Nephropathy in Fischer-344 (F-344/N) Rats
Toxicol Pathol, June 1, 1993; 21(4): 353 - 361.
[Abstract] [PDF]

				K. P. Keenan, C.-M. Hoe, L. Mixson, C. L. Mccoy, J. B. Coleman, B. A. Mattson, G. A. Ballam, L. A. Gumprecht, and K. A. Soper Diabesity: A Polygenic Model of Dietary-Induced Obesity from Ad Libitum Overfeeding of Sprague-Dawley Rats and Its Modulation by Moderate and Marked Dietary Restriction Toxicol Pathol, October 1, 2005; 33(6): 650 - 674. [Abstract] [Full Text] [PDF]

				M. D. W. Piper, W. Mair, and L. Partridge Counting the Calories: The Role of Specific Nutrients in Extension of Life Span by Food Restriction J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2005; 60(5): 549 - 555. [Abstract] [Full Text] [PDF]

				D. L. Mattson, C. J. Meister, and M. L. Marcelle Dietary Protein Source Determines the Degree of Hypertension and Renal Disease in the Dahl Salt-Sensitive Rat Hypertension, April 1, 2005; 45(4): 736 - 741. [Abstract] [Full Text] [PDF]

				W. T. Cefalu, Z. Q. Wang, A. D. Bell-Farrow, J. Collins, T. Morgan, and J. D. Wagner Caloric Restriction and Cardiovascular Aging in Cynomolgus Monkeys (Macaca fascicularis): Metabolic, Physiologic, and Atherosclerotic Measures From a 4-Year Intervention Trial J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2004; 59(10): B1007 - B1014. [Abstract] [Full Text] [PDF]

				J. W. Kim, Y. Zou, S. Yoon, J. H. Lee, Y. K. Kim, B. P. Yu, and H. Y. Chung Vascular Aging: Molecular Modulation of the Prostanoid Cascade by Calorie Restriction J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2004; 59(9): B876 - B885. [Abstract] [Full Text] [PDF]

				D. E. Fair, M. R. Ogborn, H. A. Weiler, N. Bankovic-Calic, E. P. Nitschmann, S. C. Fitzpatrick-Wong, and H. M. Aukema Dietary Soy Protein Attenuates Renal Disease Progression After 1 and 3 Weeks in Han:SPRD-cy Weanling Rats J. Nutr., June 1, 2004; 134(6): 1504 - 1507. [Abstract] [Full Text] [PDF]

				G. C. Hard and Kanwar Nasir Khan Invited Review: A Contemporary Overview of Chronic Progressive Nephropathy in the Laboratory Rat, and Its Significance for Human Risk Assessment Toxicol Pathol, February 1, 2004; 32(2): 171 - 180. [Abstract] [PDF]

				D. J. Holmes F344 Rat Sci. Aging Knowl. Environ., September 10, 2003; 2003(36): as2 - 2. [Abstract] [Full Text]

				B. S. Kristal and U. Paolucci Caloric Restriction in trans Sci. Aging Knowl. Environ., July 9, 2003; 2003(27): pe19 - 19. [Abstract] [Full Text]

				S. R. Teixeira, K. A. Tappenden, and J. W. Erdman Jr. Altering Dietary Protein Type and Quantity Reduces Urinary Albumin Excretion without Affecting Plasma Glucose Concentrations in BKS.cg-m +Leprdb/+Leprdb (db/db) Mice J. Nutr., March 1, 2003; 133(3): 673 - 678. [Abstract] [Full Text] [PDF]

				G. N. Rao Diet and Kidney Diseases in Rats Toxicol Pathol, October 1, 2002; 30(6): 651 - 656. [Abstract] [PDF]

				H. Shi, K. E. Vigneau-Callahan, A. I. Shestopalov, P. E. Milbury, W. R. Matson, and B. S. Kristal Characterization of Diet-Dependent Metabolic Serotypes: Proof of Principle in Female and Male Rats J. Nutr., May 1, 2002; 132(5): 1031 - 1038. [Abstract] [Full Text] [PDF]

				G. N. Rao, R. W. Morris, and J. C. Seely Beneficial Effects of NTP-2000 Diet on Growth, Survival, and Kidney and Heart Diseases of Fischer 344 Rats in Chronic Studies Toxicol. Sci., October 1, 2001; 63(2): 245 - 255. [Abstract] [Full Text] [PDF]

				S. Molon-Noblot, K. P. Keenan, J. B. Coleman, C.-M. Hoe, and P. Laroque The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pancreatic Islet Pathology in Sprague--Dawley Rats Toxicol Pathol, April 1, 2001; 29(3): 353 - 362. [Abstract] [PDF]

				K. E. Vigneau-Callahan, A. I. Shestopalov, P. E. Milbury, W. R. Matson, and B. S. Kristal Characterization of Diet-Dependent Metabolic Serotypes: Analytical and Biological Variability Issues in Rats J. Nutr., March 1, 2001; 131(3): 924S - 932. [Abstract] [Full Text]

				M. Kemi, K. P. Keenan, C. Mccoy, C.-M. Hoe, K. A. Soper, G. C. Ballam, and M. J. Van Zwieten The Relative Protective Effects of Moderate Dietary Restriction versus Dietary Modification on Spontaneous Cardiomyopathy in Male Sprague-Dawley Rats Toxicol Pathol, March 1, 2000; 28(2): 285 - 296. [Abstract] [PDF]

				H. M. AUKEMA, I. HOUSINI, and J. M. RAWLING Dietary Soy Protein Effects on Inherited Polycystic Kidney Disease Are Influenced by Gender and Protein Level J. Am. Soc. Nephrol., February 1, 1999; 10(2): 300 - 308. [Abstract] [Full Text]

				K. P Keenan Effects of Diet and Overfeeding On Body Weight and Survival in the Rodent Bioassay: the Impact On Pharmaceutical Safety Assessment International Journal of Toxicology, January 1, 1998; 17(2_suppl): 101 - 117. [Abstract] [PDF]

				S. Klebanov, J. T. Herlihy, and G. L. Freeman Effect of long-term food restriction on cardiac mechanics Am J Physiol Heart Circ Physiol, November 1, 1997; 273(5): H2333 - H2342. [Abstract] [Full Text] [PDF]

				K. P Keenan, P. Laroque, G. C. Ballam, K. A. Soper, R. Dixit, B. A. Mattson, S. P Adams, and J. B. Coleman The Effects of Diet, Ad Libitum Overfeeding, and Moderate Dietary Restriction on the Rodent Bioassay: The Uncontrolled Variable in Safety Assessment Toxicol Pathol, November 1, 1996; 24(6): 757 - 768. [Abstract] [PDF]

				K. P. Keenan Commentary: The Uncontrolled Variable in Risk Assessment: Ad Libitum Overfed Rodents-Fat, Facts and Fiction Toxicol Pathol, May 1, 1996; 24(3): 376 - 383. [PDF]

				K. P. Keenan, K. A. Soper, P. R. Hertzog, L. A. Gumprecht, P. F. Smith, B. A. Mattson, G. C. Ballam, and R. L. Clark Diet, Overfeeding, and Moderate Dietary Restriction in Control Sprague-Dawley Rats: II. Effects on Age-Related Proliferative and Degenerative Lesions Toxicol Pathol, May 1, 1995; 23(3): 287 - 302. [Abstract] [PDF]

				L. A. Gumprecht, C. Y. R. Long, K. A. Soper, P. F. Smith, W. M. Haschek-Hock, and K. P. Keenan The Early Effects of Dietary Restriction on the Pathogenesis of Chronic Renal Disease in Sprague-Dawley Rats at 12 Months Toxicol Pathol, November 1, 1993; 21(6): 528 - 537. [Abstract] [PDF]

				G. N. Rao, J. Edmondson, and M. R. Elwell Influence of Dietary Protein Concentration on Severity of Nephropathy in Fischer-344 (F-344/N) Rats Toxicol Pathol, June 1, 1993; 21(4): 353 - 361. [Abstract] [PDF]