© 1985 The Gerontological Society of America
Nutritional Influences on Aging of Fischer 344 Rats: II. Pathology1
2 Department of Physiology. the University of Texas Health Science Center San Antonio. Texas 78284
3 Department of Pathology. the University of Texas Health Science Center San Antonio, Texas 78284
4 Current Address: Department of Pathology. Nagasaki Medical School Nagasaki. Japan
5 Current Address: Department of Internal Medicine, Nagasaki Medical School Nagasaki, Japan
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Abstract |
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The aim of this study was to explore the effects of nutritional manipulations on the occurrence and progression of age-related pathologic lesions in male Fischer 344 rats. The following nutritional regimens were studied: (a) ad libitum feeding, (b) food restriction initiated at 6 weeks of age, (c) food restriction initiated at 6 months of age, (d) food restriction limited to a period of early life (6 weeks to 6 months of age), (e) protein restriction without caloric restriction. The major age-related lesions observed were chronic nephropathy, cardiomyopathy, and neoplasia. Food restriction initiated at 6 months of age was as effective as food restriction initiated at 6 weeks of age in slowing the progression of chronic nephropathy and cardiomyopathy and in delaying the occurrence of neoplasia. Food restriction limited to early life was much less effective. Protein restriction in the absence of caloric restriction did not delay the occurrence of neoplasia, but it did retard chronic nephropathy and cardiomyopathy, although much less effectively than caloric restriction involving a similar level of protein restriction.
Key Words: Food restriction • Protein restriction • Chronic nephropathy • Cardiomyopathy • Neoplasm • Longevity • Serum creatinine • Serum urea-nitrogen • Osteodystrophy • Interstitial cell tumors • Age-related • Disease
1 The authors wish to thank John Rodriguez. Emilio Garcia. Juan Parra. Paul Sanchez and Gilbert Aldrete for their excellent technical support. The research was supported in part by grant number AGO 1188 from the National Institute on Aging of the National Institutes of Health.
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|
|
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|
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|
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|
|
|
|
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|
|
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|
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|
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 |
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
K. P. Keenan, K. A. Soper, P. F. Smith, G. C. Ballam, and R. L. Clark Diet, Overfeeding, and Moderate Dietary Restriction in Control Sprague-Dawley Rats: I. Effects on Spontaneous Neoplasms Toxicol Pathol, May 1, 1995; 23(3): 269 - 286. [Abstract] [PDF]
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|
|
|
|
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K. P. Keenan, K. A. Soper, P. R. Hertzog, L. A. Gumprecht, P. F. Smith, B. A. Mattson, G. C. Ballam, and R. L. Clark Diet, Overfeeding, and Moderate Dietary Restriction in Control Sprague-Dawley Rats: II. Effects on Age-Related Proliferative and Degenerative Lesions Toxicol Pathol, May 1, 1995; 23(3): 287 - 302. [Abstract] [PDF]
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|
|
|
|
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K. P. Keenan, P. F. Smith, P. Hertzog, K. Soper, G. C. Ballam, and R. L. Clark The Effects of Overfeeding and Dietary Restriction on Sprague-Dawley Rat Survival and Early Pathology Biomarkers of Aging Toxicol Pathol, May 1, 1994; 22(3): 300 - 315. [Abstract] [PDF]
|
|
|
|
|
|
J. D. Thurman, T. J. Bucci, R. W. Hart, and A. Turturro Survival, Body Weight, and Spontaneous Neoplasms in Ad Libitum- Fed and Food-Restricted Fischer-344 Rats Toxicol Pathol, January 1, 1994; 22(1): 1 - 9. [Abstract] [PDF]
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|
|
|
|
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G. N. Rao, J. Edmondson, and M. R. Elwell Influence of Dietary Protein Concentration on Severity of Nephropathy in Fischer-344 (F-344/N) Rats Toxicol Pathol, June 1, 1993; 21(4): 353 - 361. [Abstract] [PDF]
|
|
|
|
 |
|
 E. J. Masoro Biology of Aging: Current State of Knowledge Arch Intern Med, January 1, 1987; 147(1): 166 - 169. [Abstract] [PDF]
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