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Journal of Gerontology 1982 37(6):648-650; doi:10.1093/geronj/37.6.648
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© 1982 The Gerontological Society of America

The Influence of Aging on Hemoglobin A1c(HbA1c)1

Bengt B. Arnetz, MD2,4, Anders Kallner, MD, PhD3 and Töres Theorell, MD, PhD4

2 Reprint requests should be addressed to the first author, Laboratory for Clinical Stress Research, Karolinska Institute! Box 60 205, S-104 01 Stockholm, Sweden
3 Department of Clinical Chemistry, the Karolinska University Hospital Stockholm, Sweden
4 National Institute for Psychosocial Factors and Health Stockholm, Sweden


  Abstract

Hemoglobin Alc (HbA1c) was used as a marker of transient increases in plasma glucose over the preceding 8 to 12 weeks in 48 nondiabetics between the ages of 50 and 89 years. A major finding is the lack of any significant differences in fasting plasma glucose with age, whereas HbA1c differed significantly between the age groups 50 to 69, 70 to 79, and 80 to 89 years. The lowest values, 6.9 ± .48%, were found among the youngest age group, whereas the highest, 8.62 ± .28%, were found in those 80 to 89 years of age.

Key Words: Carbohydrate metabolism • Glucose • Human

1 This study was supported by grants from Karolinska Institute and Claes Groschinsky's memory foundation. Sincere gratitude is expressed to the staff at the laboratory of Dalen's Hospital for their unlimited assistance, as well as to Mrs. Judith Ametz for correcting the English and for critical advice and Mrs. Birgitta Hartstein for excellent secretarial work.


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