Skip Navigation

Journal of Gerontology 1981 36(3):259-279; doi:10.1093/geronj/36.3.259
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kroes, R.
Right arrow Articles by Nesselrooy, J. H. J. v.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1981 The Gerontological Society of America

Histopathological Profile of a Wistar Rat Stock Including a Survey of the Literature1

Robert Kroes, DVM2,4, Johanna M. Garbis-Berkvens, BSc2, Theun de Vries3 and Johannes H. J. van Nesselrooy2

2 Laboratory of Pathology, National Inst. of Public Health Bilthoven, The Netherlands
3 Laboratory of Toxicology, National Inst. of Public Health Bilthoven, The Netherlands


  Abstract

This study is concerned with the histopathological changes and tumors and their incidences in the Wistar SPF Tox rat. Also included are data on survival, growth and haematology. The animals were untreated and were investigated for 30 months. The data are compared with those from two Wistar substocks, which had been used in the same laboratory: the Wistar CPB and the Wistar Conv. The results are summarized in tables and figures and are compared with data from the literature. A survey of studies dealing with spontaneous lesions and tumors in rats is given.

A wide variety of tumor types and a relatively high tumor incidence were found in the Wistar SPF Tox rats. Since most of the tumors were found after 24 months, this high incidence was correlated with the life expectancy.

Key Words: Histopathology • Spontaneous lesions • Tumor incidence • Wistar rat

1 The authors wish to express their gratitude to Dr. P. W. Helleman and Miss M. C. M. Geleijnse for performing the haematological studies, to Mr. J. Weiss for his helpful assistance in the collection of the pertinent literature and to Dr. E. J. Ruitenberg, Dr. G. van Steenis and Dr. A. C. Ford for their critical remarks on the manuscript.

4 Present address: Central Inst. for Nutrition & Food Research, T.N.O., P.O. Box 360, 3700 AJ Zeist, The Netherlands.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Toxicol PatholHome page
C. S. Elangbam, K. A. Colman, R. M. Lightfoot, R. D. Tyler, and H. G. Wall
Endocardial Myxomatous Change in Harlan Sprague-Dawley Rats (Hsd:S--D) and CD-1 Mice: Its Microscopic Resemblance to Drug-Induced Valvulopathy in Humans
Toxicol Pathol, June 1, 2002; 30(4): 483 - 491.
[Abstract] [PDF]

Home page
 Toxicol PatholHome page
M. M. Sommer
Spontaneous Skin Neoplasms in Long-Evans Rats
Toxicol Pathol, September 1, 1997; 25(5): 506 - 510.
[Abstract] [PDF]

Home page
 Toxicol PatholHome page
J. M. Ward, H. Uno, and C. H. Frith
Immunohistochemistry and Morphology of Reactive Lesions in Lymph Nodes and Spleen from Rats and Mice
Toxicol Pathol, January 1, 1993; 21(2): 199 - 205.
[Abstract] [PDF]

Home page
 Toxicol PatholHome page
J. H. J. Van Nesselrooij, F. G.J. Hendriksen, V. J. Feron, and M. C. Bosland
Pathogenesis of Blood-Filled Cavities in Estrogen-Induced Anterior Pituitary Tumors in Male Sprague-Dawley Rats
Toxicol Pathol, January 1, 1992; 20(1): 71 - 80.
[Abstract] [PDF]

Home page
 Toxicol PatholHome page
H. A. Solleveld and G. A. Boorman
Spontaneous Renal Lesions in Five Rat Strains
Toxicol Pathol, February 1, 1986; 14(2): 168 - 174.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.