© 1977 The Gerontological Society of America
Pathological Changes During Aging in, Barrier-Reared Fischer 344 Male Rats1
2 Univ. of Otago, Dunedin New Zealand.
3 Yale Univ. School of Medicine New Haven, CT 06510.
4 Yale Univ. School of Medicine New Haven, CT 06510.
5 Yale Univ. School of Medicine New Haven, CT 06510.
6 Charles River Breeding Labs, Wilmington, MA.
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Abstract |
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Pathology, microbiology, and selected serum chemistries were evaluated in 144 male Fischer rats from 4 to 33 mo of age. The rats were reared and maintained under barrier conditions, which successfully excluded the introduction of major infectious disease agents throughout the entire study, including Mycoplasma pulmonis. A wide variety of pathology was found and tabulated, and many lesions were found to increase in severity and incidence with age. There was a high correlation of renal disease severity with increasing age. Serum total protein and albumin decreased with age, while alpha-1 globulin and cholesterol increased.
1 This work supported by the National Institute on Aging, research contract number AG-3-2725. The authors recognize the contributions of Dr. D. Gibson and H. Hoffman. Send reprint requests to AMJ.
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