© 1976 The Gerontological Society of America
The Effect of Age on Creatinine Clearance in Men: A Cross-sectional and Longitudinal Study2
1 Clinical Physiology Branch, Gerontology Research Center, National Institute on Aging, Baltimore City Hospitals Baltimore 21224. Reprint requests to Dr. Rowe.
 |
Abstract |
|---|
Standard true 24-hour creatinine clearance determinations were performed on 884 subjects of the Baltimore Longitudinal Study. On the basis of clinical data, subjects were placed in categories indicating the presence of specific diseases or medications which might alter glomerular filtration rate. Subjects not included in these categories were considered normal (N = 548). In the normals, cross-sectional analysis by 10-year age groups showed a progressive linear decline in clearance from 140 ml/min/ 1.73m2 at age 30 to 97 at age 80. Three or more serial clearances were obtained at 12-to 18-mo. Intervals on 293 normal subjects. These longitudinal data showed an acceleration of the rate of decline in creatinine clearance with advancing age. The decrease in creatinine clearance with age seen in this study represents true renal aging and is not secondary to diseases which become increasingly prevalent in the elderly. A nomogram constructed from these data provides normative age-corrected standards for creatinine clearance
2 This work was presented at the 9th Annual Meeting of Gerontological society, Miami Beach, Nov. 8, 1973. The authors wish to acknowledge the statistical guidance of Dr. James Schlesselman of the Biometry Branch, NICHD. Elsie beard and Marvin Yiengst provided technical assistance
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. C. Odden, I. B. Tager, R. T. Gansevoort, S. J. L. Bakker, R. Katz, L. F. Fried, A. B. Newman, R. B. Canada, T. Harris, M. J. Sarnak, et al. Age and cystatin C in healthy adults: a collaborative study Nephrol. Dial. Transplant., September 11, 2009; (2009) gfp474v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. S. Smith Opioid Metabolism Mayo Clin. Proc., July 1, 2009; 84(7): 613 - 624. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.A. O'Callaghan Chronic kidney disease--assessing the impact QJM, June 1, 2009; 102(6): 431 - 433. [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Glassock and C. G. Winearls eGFR: Readjusting Its Rating Clin. J. Am. Soc. Nephrol., May 1, 2009; 4(5): 867 - 869. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Subherwal, R. G. Bach, A. Y. Chen, B. F. Gage, S. V. Rao, L. K. Newby, T. Y. Wang, W. B. Gibler, E. M. Ohman, M. T. Roe, et al. Baseline Risk of Major Bleeding in Non-ST-Segment-Elevation Myocardial Infarction: The CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) Bleeding Score Circulation, April 14, 2009; 119(14): 1873 - 1882. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Dawson-Hughes, S. S. Harris, N. J. Palermo, C. Castaneda-Sceppa, H. M. Rasmussen, and G. E. Dallal Treatment with Potassium Bicarbonate Lowers Calcium Excretion and Bone Resorption in Older Men and Women J. Clin. Endocrinol. Metab., January 1, 2009; 94(1): 96 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lin and G. C. Curhan Kidney function decline and physical function in women Nephrol. Dial. Transplant., September 1, 2008; 23(9): 2827 - 2833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Metter, B. G. Windham, M. Maggio, E. M. Simonsick, S. M. Ling, J. M. Egan, and L. Ferrucci Glucose and Insulin Measurements from the Oral Glucose Tolerance Test and Mortality Prediction Diabetes Care, May 1, 2008; 31(5): 1026 - 1030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Carter, S. E. O'Riordan, G. L. Eaglestone, M. P. Delaney, and E. J. Lamb Chronic kidney disease prevalence in a UK residential care home population Nephrol. Dial. Transplant., April 1, 2008; 23(4): 1257 - 1264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Bates, J. E. Campbell, M. Broce, P. S. Lavigne, and M. A. Riley Serum Creatinine Stabilization Following Renal Artery Stenting Vascular and Endovascular Surgery, March 1, 2008; 42(1): 40 - 46. [Abstract] [PDF]
|
|
|
|
 |
|
 M. J. Sarnak, R. Katz, L. F. Fried, D. Siscovick, B. Kestenbaum, S. Seliger, D. Rifkin, R. Tracy, A. B. Newman, M. G. Shlipak, et al. Cystatin C and Aging Success Arch Intern Med, January 28, 2008; 168(2): 147 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shinkai, P. H. M. Chaves, Y. Fujiwara, S. Watanabe, H. Shibata, H. Yoshida, and T. Suzuki {beta}2-Microglobulin for Risk Stratification of Total Mortality in the Elderly Population: Comparison With Cystatin C and C-Reactive Protein Arch Intern Med, January 28, 2008; 168(2): 200 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. F. Ferraro and M. H. Schafer Gerontology's Greatest Hits J. Gerontol. B. Psychol. Sci. Soc. Sci., January 1, 2008; 63(1): S3 - S6. [Full Text] [PDF]
|
|
|
|
|
|
M. S. MacGregor How common is early chronic kidney disease?: A Background Paper prepared for the UK Consensus Conference on Early Chronic Kidney Disease Nephrol. Dial. Transplant., September 1, 2007; 22(suppl_9): ix8 - ix18. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tanaka, H. Kato, I. Kojima, T. Ohse, D. Son, T. Tawakami, T. Yatagawa, R. Inagi, T. Fujita, and M. Nangaku Hypoxia and expression of hypoxia-inducible factor in the aging kidney. J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2006; 61(8): 795 - 805. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Sechi, M. Novello, R. Lapenna, S. Baroselli, E. Nadalini, G. L. Colussi, and C. Catena Long-term renal outcomes in patients with primary aldosteronism. JAMA, June 14, 2006; 295(22): 2638 - 2645. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Manunta, B. P. Hamilton, and J. M. Hamlyn Salt intake and depletion increase circulating levels of endogenous ouabain in normal men Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R553 - R559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Maaravi, M. Bursztyn, R. Hammerman-Rozenberg, A. Cohen, and J. Stessman Moderate renal insufficiency at 70 years predicts mortality QJM, February 1, 2006; 99(2): 97 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Mentes, B. Wakefield, and K. Culp Use of a urine color chart to monitor hydration status in nursing home residents. Biol Res Nurs, January 1, 2006; 7(3): 197 - 203. [Abstract] [PDF]
|
|
|
|
 |
|
 R. H Boger Renal impairment: a challenge for opioid treatment? The role of buprenorphine Palliative Medicine, January 1, 2006; 20(8_suppl): 17 - 23. [Abstract] [PDF]
|
|
|
|
|
|
A. Ble, J. C. Fink, R. C. Woodman, M. A. Klausner, B. G. Windham, J. M. Guralnik, and L. Ferrucci Renal Function, Erythropoietin, and Anemia of Older Persons: The InCHIANTI Study Arch Intern Med, October 24, 2005; 165(19): 2222 - 2227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Meneilly Diabetes Is Common in Elderly Persons J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2005; 60(9): 1145 - 1146. [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Rowan, R. E. Ramsay, J. F. Collins, F. Pryor, K. D. Boardman, B. M. Uthman, M. Spitz, T. Frederick, A. Towne, G. S. Carter, et al. New onset geriatric epilepsy: A randomized study of gabapentin, lamotrigine, and carbamazepine Neurology, June 14, 2005; 64(11): 1868 - 1873. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Meneton, X. Jeunemaitre, H. E. de Wardener, and G. A. Macgregor Links Between Dietary Salt Intake, Renal Salt Handling, Blood Pressure, and Cardiovascular Diseases Physiol Rev, April 1, 2005; 85(2): 679 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Morley A Brief History of Geriatrics J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2004; 59(11): 1132 - 1152. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Argiris, Y. Li, B. A. Murphy, C. J. Langer, and A. A. Forastiere Outcome of Elderly Patients With Recurrent or Metastatic Head and Neck Cancer Treated With Cisplatin-Based Chemotherapy J. Clin. Oncol., January 15, 2004; 22(2): 262 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bressler and J. J. Bahl Principles of Drug Therapy for the Elderly Patient Mayo Clin. Proc., December 1, 2003; 78(12): 1564 - 1577. [Abstract] [PDF]
|
|
|
|
 |
|
 V K Podichetty, D J Mazanec, and R S Biscup Chronic non-malignant musculoskeletal pain in older adults: clinical issues and opioid intervention Postgrad. Med. J., November 1, 2003; 79(937): 627 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Luckey and C. J. Parsa Fluid and Electrolytes in the Aged Arch Surg, October 1, 2003; 138(10): 1055 - 1060. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Levey, J. Coresh, E. Balk, A. T. Kausz, A. Levin, M. W. Steffes, R. J. Hogg, R. D. Perrone, J. Lau, and G. Eknoyan National Kidney Foundation Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification, and Stratification Ann Intern Med, July 15, 2003; 139(2): 137 - 147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ishida, H. Ishida, M. Narita, T. Sairenchi, Y. Saito, H. Fukutomi, H. Takahashi, K. Yamagata, and A. Koyama Factors affecting renal function in 119 985 adults over three years QJM, October 1, 2001; 94(10): 541 - 550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-H. Parving, H. Lehnert, J. Brochner-Mortensen, R. Gomis, S. Andersen, P. Arner, and the Irbesartan in Patients with Type 2 Diabetes an The Effect of Irbesartan on the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes N. Engl. J. Med., September 20, 2001; 345(12): 870 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. F. Culleton, M. G. Larson, J. C. Evans, P. W. F. Wilson, B. J. Barrett, P. S. Parfrey, and D. Levy Prevalence and Correlates of Elevated Serum Creatinine Levels: The Framingham Heart Study Arch Intern Med, August 9, 1999; 159(15): 1785 - 1790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. H. Cheng, L. D. Plank, and G. L. Hill Prolonged Overexpansion of Extracellular Water in Elderly Patients With Sepsis Arch Surg, July 1, 1998; 133(7): 745 - 751. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Dengel, R. V. Hogikyan, M. D. Brown, S. G. Glickman, and M. A. Supiano Insulin sensitivity is associated with blood pressure response to sodium in older hypertensives Am J Physiol Endocrinol Metab, March 1, 1998; 274(3): E403 - E409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Heppner, J. Kotzka, C. Bullmann, W. Krone, and D. Müller-Wieland Identification of Mutations of the Arginine Vasopressin-Neurophysin II Gene in Two Kindreds with Familial Central Diabetes Insipidus J. Clin. Endocrinol. Metab., February 1, 1998; 83(2): 693 - 696. [Abstract] [Full Text]
|
|
|
|
|
|
S. G. Chrysant, M. R. Weir, A. B. Weder, D. A. McCarron, M. Canossa-Terris, J. D. Cohen, R. F. Mennella, L. W. Kirkegaard, A. J. Lewin, and M. H. Weinberger There Are No Racial, Age, Sex, or Weight Differences in the Effect of Salt on Blood Pressure in Salt-Sensitive Hypertensive Patients Arch Intern Med, November 24, 1997; 157(21): 2489 - 2494. [Abstract] [PDF]
|
|
|
|
 |
|
 A Kumar, N Edward, M I White, P W Johnston, and G R D Catto Lesson of the Week: Allopurinol, erythema multiforme, and renal insufficiency BMJ, January 20, 1996; 312(7024): 173 - 174. [Full Text]
|
|
|
|
|
|
A. D. Weinberg, K. L. Minaker, Council on Scientific Affairs, American Medical As, Y. D. Coble Jr, R. M. Davis, C. A. Head, J. P. Howe III, M. S. Karlan, W. R. Kennedy, P. J. Numann, et al. Dehydration: Evaluation and Management in Older Adults JAMA, November 15, 1995; 274(19): 1552 - 1556. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Manttari, E. Tiula, T. Alikoski, and V. Manninen Effects of Hypertension and Dyslipidemia on the Decline in Renal Function Hypertension, October 1, 1995; 26(4): 670 - 675. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. C. Cloyd, T. E. Lackner, and I. E. Leppik Antiepileptics in the Elderly: Pharmacoepidemiology and Pharmacokinetics Arch Fam Med, July 1, 1994; 3(7): 589 - 598. [Abstract] [PDF]
|
|
|
|
 |
|
 A. L. Buchman, A. Moukarzel, M. E. Ament, J. Gornbein, B. Goodson, C. Carlson, and R. A. Hawkins Serious Renal Impairment Is Associated With Long-Term Parenteral Nutrition JPEN J Parenter Enteral Nutr, September 1, 1993; 17(5): 438 - 444. [Abstract] [PDF]
|
|
|
|
|
|
T. C. Markello, I. M. Bernardini, and W. A. Gahl Improved Renal Function in Children with Cystinosis Treated with Cysteamine N. Engl. J. Med., April 22, 1993; 328(16): 1157 - 1162. [Abstract] [Full Text]
|
|
|
|
|
|
W. G. Walker, J. D. Neaton, J. A. Cutler, R. Neuwirth, J. D. Cohen, and MRFIT Research Group Renal Function Change in Hypertensive Members of the Multiple Risk Factor Intervention Trial: Racial and Treatment Effects JAMA, December 2, 1992; 268(21): 3085 - 3091. [Abstract] [PDF]
|
|
|
|
|
|
L. A. Lipsitz and A. L. Goldberger Loss of 'Complexity' and Aging: Potential Applications of Fractals and Chaos Theory to Senescence JAMA, April 1, 1992; 267(13): 1806 - 1809. [Abstract] [PDF]
|
|
|
|
|
|
J. H. Gurwitz and J. Avorn The Ambiguous Relation between Aging and Adverse Drug Reactions Ann Intern Med, June 1, 1991; 114(11): 956 - 966. [Abstract] [PDF]
|
|
|
|
|
|
W. B. Applegate Hypertension in Elderly Patients Ann Intern Med, June 1, 1989; 110(11): 901 - 915. [Abstract] [PDF]
|
|
|
|
|
|
R. J. Cody, S. Torre, M. Clark, and K. Pondolfino Age-Related Hemodynamic, Renal, and Hormonal Differences Among Patients With Congestive Heart Failure Arch Intern Med, May 1, 1989; 149(5): 1023 - 1028. [Abstract] [PDF]
|
|
|
|
 |
|
 P. S. German and L. C. Burton Medication and the Elderly: Issues of Prescription and Use J Aging Health, February 1, 1989; 1(1): 4 - 34. [Abstract] [PDF]
|
|
|
|
|
|
J. E. Morley, A. D. Mooradian, A. J. Silver, D. Heber, and R. B. Alfin-Slater Nutrition in the Elderly Ann Intern Med, December 1, 1988; 109(11): 890 - 904. [Abstract] [PDF]
|
|
|
|
 |
|
 M. A. Jenike Assessment and Treatment of Affective Illness in the Elderly J Geriatr Psychiatry Neurol, April 1, 1988; 1(2): 89 - 107. [PDF]
|
|
|
|
|
|
N. A. SNYDER, D. W. FEIGAL, and A. I. ARIEFF Hypernatremia in Elderly Patients: A Heterogeneous, Morbid, and Iatrogenic Entity Ann Intern Med, September 1, 1987; 107(3): 309 - 319. [Abstract] [PDF]
|
|
|
|
|
|
M. Walser Creatinine Excretion as a Measure of Protein Nutrition in Adults of Varying Age JPEN J Parenter Enteral Nutr, September 1, 1987; 11(5_suppl): 73S - 78S. [Abstract] [PDF]
|
|
|
|
|
|
T. H. Goldberg and M. S. Finkelstein Difficulties in Estimating Glomerular Filtration Rate in the Elderly Arch Intern Med, August 1, 1987; 147(8): 1430 - 1433. [Abstract] [PDF]
|
|
|
|
|
|
E. W. Campion, J. Avorn, V. A. Reder, and N. J. Olins Overmedication of the Low-Weight Elderly Arch Intern Med, May 1, 1987; 147(5): 945 - 947. [Abstract] [PDF]
|
|
|
|
 |
|
 H.H. Chauncey, R.P. Feller, and K.K. Kapur Longitudinal Age-related Changes in Human Parotid Saliva Composition Journal of Dental Research, February 1, 1987; 66(2): 599 - 602. [PDF]
|
|
|
|
|
|
E. J. Masoro Biology of Aging: Current State of Knowledge Arch Intern Med, January 1, 1987; 147(1): 166 - 169. [Abstract] [PDF]
|
|
|
|
|
|
W. W. Brown, B. B. Davis, L. A. Spry, N. Wongsurawat, J. D. Malone, and D. T. Domoto Aging and the Kidney Arch Intern Med, September 1, 1986; 146(9): 1790 - 1796. [Abstract] [PDF]
|
|
|
|
 |
|
 B. H. Brouhard The Role of Dietary Protein in Progressive Renal Disease Arch Pediatr Adolesc Med, July 1, 1986; 140(7): 630 - 637. [Abstract] [PDF]
|
|
|
|
|
|
S. G. TAYLOR IV, R. S. GELMAN, G. FALKSON, and F. J. CUMMINGS Combination Chemotherapy Compared to Tamoxifen as Initial Therapy for Stage IV Breast Cancer in Elderly Women Ann Intern Med, April 1, 1986; 104(4): 455 - 461. [Abstract] [PDF]
|
|
|
|
|
|
T. W. MEYER, S. ANDERSON, and B. M. BRENNER Dietary Protein Intake and Progressive Glomerular Sclerosis: The Role of Capillary Hypertension and Hyperperfusion in the Progression of Renal Disease Ann Intern Med, May 1, 1983; 98(5_Part_2): 832 - 838. [Abstract] [PDF]
|
|
|
|
|
|
C.O. Mitchell and D. A. Lipschitz Arm Length Measurement as an Alternative to Height in Nutritional Assessment of the Elderly JPEN J Parenter Enteral Nutr, May 1, 1982; 6(3): 226 - 229. [Abstract] [PDF]
|
|
|
|
|
|
J. G. OUSLANDER Drug Therapy in the Elderly Ann Intern Med, December 1, 1981; 95(6): 711 - 722. [Abstract] [PDF]
|
|
|
|
|
|
R. LOFGREN and T. W. CROWSON Diagnostic Tests and Procedures Ann Intern Med, September 1, 1981; 95(3): 387 - 389. [Abstract] [PDF]
|
|
|
|
|
|
B.J. Baum Clinical Science: Evaluation of Stimulated Parotid Saliva Flow Rate in Different Age Groups Journal of Dental Research, July 1, 1981; 60(7): 1292 - 1296. [Abstract] [PDF]
|
|