© 1973 The Gerontological Society of America
Possible Immune Origin of Age-Related Pathological Changes in Long-Lived Mice1
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Tissues from aging BC3F1 mice were examined to determine the prevalance and nature of diseases of possible immunologic origin. Pathological conditions detected were: glomerulosclerosis, amyloidosis, polyarteritis and arterial hyalinization, and perivascular lymphoid and plasma cell infiltration of various tissues. Glomerular deposition of gamma globulin was observed in 38 of 44 mice. When duplicate sections were stained for murine leukemia viral antigen, 10 of 18 mice showed a positive reaction. Ultrastructural examination of the glomeruli revealed mesangial-cell proliferation, basementmembrane thickening, and deposits of electron-dense material. Amyloidosis, found in 4 of 47 mice, was confined to the marginal zone of the splenic follicle. Polyarteritis and arterial hyalinization were very rare in this hybrid. Varying degrees of perivascular lymphoid and plasma-cell infiltration in liver, kidney, lung and pancreas were observed in over 50% of the mice examined. Comparison with well-documented immunologic diseases of various species lead us to suggest that these diseases in BCF31i mice are immunologic in nature.
1 Research sponsored by the United States Atomic Energy Commission under contract with the Union Carbide Corporation.
2 Present Address: Merck Sharp & Dohme, West Point, Pa. 19486.
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